A literature review on Haemostatic disorder( VWF and Antithrombin) in prostate cancer patient

Abstract

Author(s): Akaba Kingsley, Aje Nkarense Ogar, and Akaba Edakabasi

Background: Prostate cancer is a significant cause of morbidity and mortality in male above forty years. Thromboembolic complication is the second cause of mortality among prostate cancer patients. Aim: these study seek to review the available literature on thrombotic complication among prostate cancer patient with emphasis on Von Willebrand Factor (VWF) and antithrombin activity among prostate cancer patients as this will help to raise the awareness of thromboprophylaxis and risk assessment score use respectively, to improve quality of life and management outcome. Method: A comprehensive literature search was performed using the internet search engineslinked to academic databases including Pubmed, Google Scholar, Ebsco, Hinari, Scopus, etc. Studies involving hemostatic disorders in Nigeria were thoroughly searched, and the references of such articles were also searched for any probable relevant informations. Conclusion: Haemostatic disorder in prostate cancer is a serious condition that is associated with increase morbidity and mortality due to it hypercoagulable and prothroembolic state. There is paucity of information on this disorder in our environment with inconsistency in the available studies. More studies with further research on the level of other natural anticoagulant are required to verify the correlation between this disorder and thromboembolic complication among prostate cancer subjects.

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