A review of advances in the diagnosis and treatment of metastatic atypical and anaplastic meningiomas

Abstract

Author(s): Olger Nano, Supriya Peshin, Shivani Modi, Daniel Rosas

Meningiomas are primary intracranial tumors of the Central Nervous System (CNS) originating in the brain or spinal cord and have an overall incidence of about 2.3-8.3 in 100,000. Meningiomas are benign tumors mostly but atypical and anaplastic meningiomas can behave aggressively with higher chance of recurrence. Meningiomas originate from specialized meningothelial cells called arachnoid cap cells and correspond to up to 26% of all intracranial lesions. However, higher-grade meningiomas are very rare. In this article, we focus on the important literature regarding classification and molecular biology of these high grade meningiomas. In addition, we elaborate on recent advancements of diagnostic tools and novel therapeutics in the management atypical and anaplastic meningiomas.

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