A study of serum malondialdehyde levels in patients of acute coronary syndrome with type-2 dm and type-2 dm patients without acute coronary syndrome

Abstract

Author(s): Sava Nanda Gopal, Arun Kumar Alagesan,Visvesvaran Salitteeswaran, Hanumath Prasad Yallanki, Kannan Rajendran, Vikrannth V.

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to impaired insulin response or insulin secretion. Malondialdehyde (MDA) is an end product of lipid peroxidation, noted to be significantly increased in type 2 diabetes which cause atherosclerotic lesions. The aim of this study is to find serum Malondialdehyde (MDA) levels in patients of acute coronary syndrome with type 2 diabetes mellitus and type 2 diabetes mellitus patients without Acute Coronary Syndrome (ACS). A total of 212 patients with Type 2 Diabetes Mellitus (T2 DM) from the Saveetha Medical College and Hospital's General Medicine department were enrolled in the study. There were 106 individuals with Type 2 DM without acute coronary syndrome and another 106 patients with Type 2 DM with acute coronary syndrome. Duration of diabetes mellitus, total cholesterol, elevated TAG, elevated Low Density Lipoprotein (LDL), low High Density Lipoprotein (HDL) were significantly associated with the development of acute coronary syndrome among diabetic patients. The mean Serum MDA among the participants in the T2DM with Acute coronary syndrome was 3.90 ± 0.44 mg/dl while among those in the T2DM without acute coronary syndrome was 1.98 ± 0.45 mg/dl. With a p value of less than 0.05, According to recent research, there is a negative correlation between MDA-LDL levels and HDL-C levels and a positive correlation with triglyceride and LDL-C levels. The traditional Cardiovascular disease risk factors including diabetes, hypertension, hyperlipidemia, and cigarette smoking are strongly linked with higher MDA levels.

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