Analiza losów chorych na niezaawansowanego raka endometrium z przerzutami do mózgu

Abstract

Author(s): Pawel Blecharz, Krzysztof Urbański, Marian Reinfuss, Anna Patla, Piotr Brandys, Elżbieta Luczyńska

The aim of the study: The presentation of treatment methods and outcomes in patients with nonadvanced endometrial cancer with brain metastases as the first symptom of treatment failure.

Material and Methods: Among 1880 patients with non-advanced endometrial cancer, treated in Center of Oncology, Cracow Branch between 1979 and 2005, brain metastases were the first sign of treatment failure in 12(0,6%). The single lesions were found in 7(58,3%) patients and multiples ones in 5(41,7%) patients. Four cases with single metastasis were treated surgically with adjuvant external beam radiotherapy XRT (2 patients) or with stereotactic radiotherapy (2 patients). The remainder patients were treated with palliative XRT and hormonotherapy (oral medroksyprogesteron).

Results: Two of 12 patients (16,7%) survived 12, 36 and 60 months. It was cases treated surgically with adjuvant XRT. Mean survival for all 12 patients was 4 month, median of survival – 2 months.

Conclusions: Distant survivals in patients with non-advanced endometrial cancer with brain dissemination are sporadic. They can be achieved thanks to surgical resection with adjuvant radiotherapy.

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