Assessment of serum levels of ESR1 and EGFR2 and human vitamin D3 as potential novel biomarkers in breast cancer patients

Abstract

Author(s): Abdalnaser K. A. Al-Zuhayri* and Firas Faris Rija

Background: Breast cancer is the most prevalent kind of cancer worldwide and the main reason why people die from cancer. Represents 18% of all malignancies in women. and second most common type of cancer after lung cancer.

Objective: In this study, ESR1, EGFR2 and human vitamin D3 were investigated in Iraqi women breast cancer patients.

Patients and methods: In this study, serum concentrations of ESR1, EGFR2 and HUMAN VITAMIN D3 were determined using samples from 90 Iraqi women (60 patients and 30 healthy volunteers) Among them are healthy and patients, premenopausal and postmenopausal woman.

Results: According to the findings of the current study, ESR1, EGFR2 and were both considerably elevated in breast cancer patients (P<0.05), and they also had a tight relationship, and human vitaminD3 was a decrease in patients with breast cancer on the probability level (P<0.05).

Conclusions: This research discovered a link between high serum levels of ESR1, EGFR2, and its inverse relationship with vitamin D.

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