Association of monocyte chemoattractant protein-1 with age, glucose, BMI, insulin and other breast cancer biomarkers

Abstract

Author(s): Jinseog Kim, Rabindra Nath Das, Youngjo Lee, Ranjan Kumar Sahoo

Breast cancer is in most cases noticed over the world as the second cause of cancer-allied death in women. Monocyte chemoattractant protein-1 (MCP1) plays an essential role in the opening and advancement of cancer. The report derives the association of MCP-1 with age, BMI, insulin, glucose and other breast cancer biomarkers such as leptin, resistin, adiponectin, HOMA based on a real data set. It is obtained herein that mean MCP-1 is positively associated with BMI (p<0.0001), resistin (p<0.0001) and the interaction effect of insulin and leptin (i.e., insulin*leptin) (p<0.0001), while it is negatively associated with insulin (p<0.0001) and leptin (p<0.0001). The variance of MCP-1 is positively associated with age*insulin (p=0.0025), leptin*resistin (p=0.0176) and glucose*leptin (p=0.0819), while it is negatively associated with age (p=0.0706), homeostasis model assessment score (HOMA) (p=0.0055), leptin (p=0.0198) and resistin (p=0.0777). Only three partially significant effects (approximately 8% level of significance) are included in the Gamma variance model, while they are significant in the Log-normal variance model. These are accounted as a confounder in the model in view of Epidemiology. It is concluded herein that MCP-1 is higher for women with high BMI, higher levels of resistin, low levels of both insulin and leptin, along with their high interaction effect.

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