Biocompatible and anti-cancer drug delivery system using gold nanoparticles stabilized with hydrophilic polymer-coated hesperidin

Abstract

Author(s): Chiranjeev Singh, Sanjay Kumar Mire

Hesperidin (HP), classified as a flavonone, is well acknowledged for its potential as a therapeutic agent with anti-inflammatory, anti-oxidative, and anti-cancer properties. Nevertheless, the compound's limited breakdown and bioavailability result in little absorption, necessitating the utilization of a delivery mechanism to reach its intended therapeutic site effectively. The utilization of Polymer-Coated (PC) Gold Nanoparticles (GNP) in current pharmacological research as a Drug Delivery System (DDS) has demonstrated efficacy for cancer therapy within the realm of biological applications. In creating pharmacological anti-cancer medications, many aspects, such as dissolution, bioavailability, biological compatibility, and restricted chemical potency, play a crucial role. These characteristics need the use of specialized formulating techniques to ensure optimal DD. The primary objective of this paper was to enhance the dissolution of the medication and mitigate the adverse effects associated with chemotherapy. A straightforward and effective approach for synthesizing Biocompatible GNP stabilized with a Hydrophilic Polymer-Coated Hesperidin (GNP-HPCH) has been presented. These nanoparticles hold promise for use in DDS. The medium, namely the polymer-enriched GNP (Au-mPEG(5000)-SH), has been produced by combining tetrachloroauric acid (HAuCl4) with the polymer. The synthesis of GNP-HPCH has been confirmed by utilizing many characterization methods, including UV-VIS spectroscopy and Transmission Electron Microscopy (TEM). The cytotoxic impact of GNP-HPCH on the female breast cancer cell line has been examined using MTT tests. GNP-HPCH, at a concentration of 100 μg/mL, demonstrates a noteworthy inhibition rate of 84% for treating breast cancer MDA-MB-231, indicating its heightened potential as an anti-cancer agent. The findings demonstrated a notable reduction in cell division and growth retardation in the treated cells when compared to the normal breast epithelial cell line

Share this article