Cancer associated venous thromboembolism and P-selectin: A review

Abstract

Author(s): Akaba kingsley, Edakabasi Akaba, Awafung Adie, Theophilus Pius

Background: Venous Thrombo Embolism (VTE) is the third most common cause of vascular mortality worldwide and comprises Deep-Vein Thrombosis (DVT) and Pulmonary Embolism (PE). It is also the second most common cause of death among cancer patients. VTE contributes immensely to the morbidity and mortality of cancer patients, with a life threaten PE being 3 times more common in cancer patients compared to non-cancer patients. Cancer patients are said to have a 5 to 7 fold increased risk of developing VTE. P-selectin can serve as a promising marker which could help to increase the precision of predicting the risk of VTE among cancer patients when combine with established validated tools.

Aim: This study seeks to unravel the increasing trend of cancer associated VTE and the intricate and multifaceted role of P-selectin in cancer associated VTE.

Method: A vigorous literature search was performed via the internet search engines linked to academic databases including PubMed, Google Scholar, Ebsco, Hinari, Scopus, etc.

Conclusion: This review underscores the dynamic of cancer associated VTE and context-dependent role of P-selectin in cancer associated VTE respectively. As we poke into the relationship between cancer, VTE and P-selectin, as this will create an insight for therapeutic intervention.

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