Combined Radiotherapy, Plant Extracts, and Chemotherapy in Colorectal Cancer Cells

Abstract

Author(s): Abbas R. Hatif, Azhar Abdul Rahman, Talib A. Abdulwahid, Naser M. Ahmed, Karrar Mahdi Badi, Ahmed Jumaah Mhawes, Laith Khaled Albadarneh

Colorectal Cancer (CRC) is a kind of cancer that is the second most common in the world, and its treatment is surgery, chemotherapy and radiation therapy. Therefore, this study investigates Fraxetin and Capsaicin's ability to prohibit CRC cells from reproducing through radiation therapy, and thus, it can serve as a viable substitute for cisplatin in CRC treatment. The largest defy is to increase the destruction of the tumour while decreasing the destruction of healthy tissue and the side effects on the surrounding normal tissues. Cells were cured with Capsaicin and Fraxetin extracts from chilli peppers and Fraxinus and radiated at 1 Gy, 3 Gy and 5 Gy. Viability has been assessed by MTT test and quantified at 570 nm in a Mutiskan EX (Thermo Lab systems). Cisplatin, conventional chemotherapy, was utilised as a positive control. Utilise of Fraxetin and Capsaicin extract showed a prospective radio-sensitising impact in a laboratory for CRC. The inhibition impact in the cell line wasn't eclectic and is extremely analogous to the impact of traditional chemotherapy. The capsaicin of chilli peppers, incorporated with radiation therapy, has been the most active extract for CRC cells.

Share this article