Commercial ZnO NPs coating on orthodontic bands and its In-Vivo evaluation

Abstract

Author(s): Mary Sheloni Missier, R. Mahesh, S.P. Saravana Dinesh, S. Rajesh kumar

Aim: The aim of this study is to compare the antimicrobial activity of Zinc Oxide coated stainless steel orthodontic bands to non-coated orthodontic band.

Materials and Method: A total number of 12 Wistar rats were randomly assigned either to the control group (Non-Coated Orthodontic Bands) or to the experimental group (Coated Orthodontic Bands) to check the antimicrobial activity of the ZnO nanoparticle. Swabs were taken at random intervals and cultured, at the end of the 30th day blood samples were collected and they were euthanized at the end of the experimental period. The antimicrobial activity of the nanoparticle and the biocompatibility of the material were analysed.

Results: Paired T-test and Independent T-test were conducted to test the equality of the antimicrobial property of non-coated stainless-steel bands and Zinc-Oxide coated stainless steel bands. Independent T-test used to compare between groups and Paired T-test was used to compare within the same group.

Conclusion: In our study we found that ZnO nanoparticles had increased antimicrobial activity. Invitro showed no signs of toxicity whereas in-vivo showed mild toxicity. Therefore, further studies are required to check their property on varied concentration of the nanoparticles.

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