Comparative of hematological and biochemical values in hemophilia patients with arthropathy and healthy persons

Abstract

Author(s): Shahad Q. Al-Hamadiny, Muthana I. Maleek, Safaa A. Faraj, Zainulabdeen AL-Badri

Background: Hemophilia is a genetic condition of bleeding that is more common in males. Although females are more likely to be carriers of hemophilia, they are not immune to the disease's severe bleeding tendencies and associated symptoms. Bleeding, especially those that reach the joints, have dire consequences if not treated properly.

Aim: study the relationship of some hematological and biochemical values in hemophilia patients with arthropathy and healthy persons, and what the differences in those values between the two cases.

The study: People suffering from hemophilia have undergone treatment at the Center of Hematology at Al-Karama teaching hospital, which is affiliated with Waist University. There were 50 patients engaged in this study, ranging in age from 3 years-45 years. It was determined that 16 of them had mild hemophilia, while the remaining 34 had severe hemophilia. While the healthy control group consisted of 25 individuals.

Results: The Hemoglobin (Hb), Red Blood Cell (RBC), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH) and Mean Corpuscular Hemoglobin Concentration (MCHC) level in Hemophilia patients (13.2 ± 2.4), (4.52 ± 0.79), (76.4 ± 9), (24.7 ± 4) and (32.3 ± 2.1) respectively are significantly decrease at (p<0.05) when compare with control (14.4 ± 1.6), (4.78 + 0.46), (84.2 ± 3.8), (27.4 ± 2.5) and (33.3 ± 1.4) to same tests. While results revealed that the Liver enzyme Alanine Transaminase (ALT), Alkaline Phosphatase (ALP), and Total Serum Bilirubin (TSB) levels in Hemophilia patients (6.1 ± 2.7), (154.9 ± 6.5), and (0.3 ± 0.2) respectively is significantly increase at (p<0.05) when compared with control group values (19.0 ± 4.7, 331.7 ± 1.5, and 0.6 ± 0.3).

Conclusions: Hepatotoxicity was intimately related with hemophilia patients with arthropathy clearly raised when increased of liver enzyme values. And decreasing in hematological values (Hb, RBC, MCV, MCH and MCHC in hemophilia patient with arthropathy.

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