Comparative study between treatment related acute toxicity in patients receiving 3DCRT/IMRT as a definitive radiotherapy for localized prostatic carcinoma with assessment of quality of life in those patients

Abstract

Author(s): Shorouk G. Badr, Samar Galal Younis, Gamal Alhusiny Atia and Fatma Gharib*

Comparative study between treatment related acute toxicity in patients receiving 3DCRT/ IMRT as a definitive radiotherapy for localized prostatic carcinoma with assessment of quality of life in those patients Shorouk G. Badr(1) , Samar Galal Younis(1), Gamal Alhusiny Atia(2), Fatma Gharib(1) (1) Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Tanta University (2) Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University Background: Prostate cancer is a leading cause of mortality and morbidity globally. In Egypt, prostate cancer comes in the sixth rank. External beam radiation therapy (EBRT) is well-established line of treatment in prostate cancer. EBRT can be delivered by many modalities including 3DCRTand IMRT. IMRT offered less gastrointestinal and genitourinary side effects and hence better health related quality of life for many patients in several studies. Aim: Comparison between acute gastrointestinal, genitourinary, hematological toxicities, fatigue related to radiotherapy and health related quality of life in patients receiving 3D conformal radiotherapy and IMRT for localized /locally advanced prostatic cancer. Patients and methods: This prospective study was carried out at clinical oncology departments Tanta university hospitals and Alexandria university hospitals through the period from May 2018 to May 2019 and included 30 intermediate and high risk prostate cancer patients received 2 modalities of radiotherapy divided into 2 arms. Fifteen patients received 3D conformal radiotherapy concurrent with ADT (Arm A) and 15 patients received IMRT concurrent with ADT (Arm B). Results: IMRT resulted in significantly lower incidence of rectal pain and microscopic hematuria and dysuria and lower incidence of grade ≥ 2 diarrhea, proctitis, rectal pain and cystitis during radiotherapy compared to 3DCRT but with little impact in overall quality of life which was better in IMRT group but without statistical significance except 6 months after radiotherapy. Conclusion: IMRT may offer lower gastrointestinal and genitourinary radiation toxicity but with no or little difference in overall health related quality of life.

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