Correlation between high risk human papilloma virus (HR-HPV) infection and vaginal microecological abnormalities

Abstract

Author(s): RongXu Li, FuChuan Wang, Xiaodi Kang, Phei Er Kee, Kai Bin Liew

Objective: To study the correlation between High-Risk Human Papillomavirus (HR-HPV) infection and vaginal microecological abnormalities, and to investigate the role of vaginal flora in HR-HPV infection.

Methods: A total of 122 HR-HPV-infected patients with negative cervical cytology, who visited the gynaecology clinic of Beijing Ditan Hospital affiliated with Capital Medical University from June 2023 to June 2024, were set as the HR-HPV (+) group. Meanwhile, 94 HPV-negative and cervical cytology-negative women who were examined during the same period were set as the HR-HPV (-) group. The infection rates of Bacterial Vaginosis (BV), Vulvovaginal Candidiasis (VVC), and Trichomonal Vaginitis (TV) were compared between the two groups.

Results: The BV infection rate in the HR-HPV (+) group (15.57%, 19/122) was higher than that in the HR-HPV (-) group (7.45%, 7/94, x2 = 3.312, p>0.05). The VVC infection rate in the HR-HPV (+) group (10.66%, 13/122) was not statistically significant different from that in the HR-HPV (-) group (8.51%, 8/94, x2 =0.598, P>0.05). The TV infection rate in the HR-HPV (+) group was 2.46% (3/122), slightly higher than in the HR-HPV (-) group (0/94), but the difference was not statistically significant (p=0.259, p>0.05).

Conclusion: BV, VVC, and TV may not be related to HR-HPV infection.

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