Correlation of p53 and Rb protein expression with Ki-67 proliferative index in urothelial carcinoma of the urinary bladder

Abstract

Author(s): Sabit Mehmeti, Rine Limani, Suzana Manxhuka-Kerliu

Genetic and environmental factors are considered to play a significant role in the development of Urothelial Carcinoma (UC) of the urinary bladder, with various molecular markers being used for diagnostic and prognostic purposes. The aim of this study was to evaluate the expression of p53, Rb and Ki-67 in UC of the urinary bladder in our population group. Additionally, we investigated potential correlations in expression between p53 and Rb, as well as their associations with the Ki-67 proliferative index in urinary bladder UC. Tissue specimens of 70 samples of UC and 20 samples of non-tumorous bladder tissue were immunohistochemically stained with primary monoclonal antibodies against p53, Rb, and Ki-67 in our single-center study. When correlating expression levels of p53, Rb, and Ki-67 statistically significant higher expression for p53 and Ki-67 (p=0.001; p<0.001, respectively) was found with increasing grade and stage in UC of the bladder. Rb expression was decreased with increasing grade and stage but not statistically significant in our study group. Our study confirms the role of p53 and Rb alterations in UC of the urinary bladder. This is the first report of p53 and Rb alterations in UC of the urinary bladder in Kosovo population

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