Czynniki rokownicze u chorych na uogólnionego raka nosowej części gardla

Abstract

Author(s): Tomasz Skóra, Bogdan Gliński, Zbigniew Wcislo, Anna Mucha-Małecka, Agnieszka Chrostowska,Dominika Wojton, Pawel Hebzda, Ewa Jakubowicz, Krzysztof Malecki, Maciej Modrzejewski

Purpose: To identify the prognostic factors for patients with disseminated nasopharyngeal carcinoma (DNC).

Material and methods: The study concerned 80 patients with DNC treated between 1995 - 2007. Forty of them received cisplatin based salvage chemotherapy, other patients were treated with palliative intent.

Results: One-year overall survival rate in the whole group was 31%, and it was 55% for patients treated with a salvage chemotherapy and 7% for receiving palliative care (p=0,0001). Both uni- and multivariate analysis demonstrated poor performance WHO/ECOG status and liver metastasis to be statistically significant for unfavorable outcomes. One-year overall survival rates for patients with WHO/ECOG values 0-1, and 2-3 were 50% and 10% respectively (p=0,0005). Liver metastasis decreased one-year overall survival from 34% to 10% (p=0,0009). There was no significant impact on overall survival of the other studied factors as age, gender, dissemination free interval, number of metastases and prior chemotherapy.

Conclusions: Patients with DNC, free of liver metastasis and having a good performance status present the most favorable outcome. This group of patients may benefit from an aggressive salvage chemotherapy.

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