Effect of mouth-care using magic solution in management of oral mucositis among patients undergoing chemotherapy

Abstract

Author(s): Murtadha Salih Radhi* and Fatma Makee Mahmood

Background: Patients how that received a chemotherapy will experience some degree of oral mucositis. It starts off as erythema and a burning sensation and can progress to extremely painful ulcerative sores, which makes it difficult for people to eat and speak and lowers their quality of life. This study was done to find out how using magic solution to manage the mouth affects how much oral mucositis a chemotherapy patient has. Method: A quasi-experimental design was used in this study conducted in the Babylon Oncology Center at Babylon governorate for the period from January, 25, 2023 to May, 17, 2023, on a sample of (40) patients undergoing chemotherapy with oral mucositis. The questionnaires where validated by experts and then it reliability was verified through a pilot study. The total number of items included in the questionnaire was 13 items for oral mucositis assessment tool, 5 items for oral toxicity, and 10 items for Challacombe scale. Data were collected by assess the oral cavity before and after applying the intervention and analyzed by applying descriptive and inferential statistical analysis. Results: The results indicate that the mean age for patients in study group is 52.2 and the mean age in control group is 51.9, the age 50 years-59 years old were recorded the highest percentage in study group (50%) and 40-49 and ≥ 60 years old in control group (30%) for each them; gender, (60%) of studied sample were female in both study and control groups; education level, half of participants were elementary school in study group (50%), and middle school of participants in control group (30%); occupation related findings, the unemployment in study and control groups were predominated (80% and 60%) respectively; smoking status, most of studied sample were not smokers (70% and 60%) respectively in study and control groups; type of chemotherapy associated findings, most of participants in study group received Taxans (50%) and in control group received Taxans and FOLFOX (40%) for each them; concerning duration of CT, patients in study and control groups expressed a 5 month and more as a duration of CT (60% and 80%) respectively; and finally with chronic comorbidities, more than half of participants were not associated (60%) in study groups and half of participants (50%) in control group. In study group, the results show that there is a significant difference in oral mucositis between two periods of measurements as a pre-test (M=2.68) (before the intervention) and a post-test (M=1.71) (after the intervention of magic solution) (t=10.837; p=0.000). In control group, the results show that there is no significant difference in oral mucositis between two periods of measurements as a pre-test (M=2.08) and a post-test (M=2.18) (after the seven days has been passed) (t=1.724; p=0.119). According to the oral toxicity, in study group findings indicate that the (50%) of patients were grade III oral toxicity before applying magic solution intervention 3.30 (± 0.82). While, at the post test after intervention of magic solution for seven days, findings indicate that the (40%) of patients were 0 and I 1.80 (± 0.78). In control group at pre and post-test. Findings indicate that the (50%) of patients were grade I oral toxicity at the pre-test 3.20 (± 0.91). While, at the post test (a seven days has been passed), findings indicate that the (80%) of patients were grade II 3.80 (± 0.42). The results of oral dryness show that there is a significant difference in oral dryness for study group between two periods of measurements as a pre-test (M=5.90) (before the intervention) and a post-test (M=2.20) (after the intervention) (t=6.398; p=0.0). In control group, the results show that there is no significant difference in oral dryness between two periods of measurements as a pre-test (M=5.80) and a post-test (M=5.20) (after the seven days has been passed) (t=.562; p=.588). Conclusions: The results of the current study demonstrated that the application of magic solution that enhanced the chemotherapy-induced oral mucositis. There is a significant statistical difference between study and control groups in treat oral mucositis. It is necessary to conduct more studies on larger sample size for identify the effect of magic solution regarding oral mucositis.

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