Effect of Platelet-Rich Plasma on function and healing of condylar fracture after closed reduction in traumatized patients

Abstract

Author(s): Mohammad Mashayekhian, Pedram Bakhshaei, Reza Tabrizi, Peyman Bakhshaei Shahrbabaki, Mehri Farhang Ranjbar, Seyed Hadi Aghili

Background: Mandibular condyle fracture is one of the most common fractures in the maxillofacial region. No researcher has yet studied the effects of Platelet-Rich Plasma (PRP) on condylar fracture healing. In this study, we aimed to evaluate the effects of PRP injection on function and recovery of the fractured mandibular condyle after closed reduction in traumatized patients. Methods and Materials: Only patients with stable and repeatable occlusion were included in this randomized clinical trial. Patients who were candidates for open reduction or those with bone or joint disease were excluded from the study. Sixty-four patients were randomly divided into two equal groups: Treatment (PRP injection after closed reduction) and control (only closed reduction). Pain intensity, Maximum Mouth Opening (MMO), and lateral movements were compared between the two groups before and after intervention. Results: Fifty-one (79.7%) patients were males, and 13 (20.3%) were females. The patients' mean (standard deviation) age was 26.18 (4.61) years. No significant difference was observed among groups considering age and gender. The pain intensity decreased significantly after the removal of MMF in the treatment group, while no significant pain reduction was observed in the control. Considering MMO and lateral movements, there was no statistically significant difference between the two groups before surgery, but they were significantly higher in the treatment group immediately after (maxillomandibular fixation) MMF. Conclusion: The current study showed that PRP injection after closed reduction can significantly reduce pain intensity in patients with condylar fractures. Also, maximum lateral movements and MMO will be higher than the control group immediately after MMF removal, but the difference between groups reduces after two weeks.

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