Ekspresja neuropiliny-2 w raku jajnika

Abstract

Author(s): Wieslawa Bednarek, Magdalena Mazurek-Kociubowska, Iwona Wertel

Introduction: Neuropilin-2 (NRP2), a transmembrane receptor, plays an important role in the distribution of lymphatic vessels. Blocking the binding of VEGF-C with neuropilin-2 by using specific antibodies, inhibits in vivo distribution of terminal lymphatic endothelial cells.

Aim: The aim of this study was to determine the expression of neuropilin-2 in ovarian cancer and to evaluate correlations with clinical features.

Material and methods: The material was collected from from 61 patients operated by the reason of ovarian cancer, between the ages of 24 to 82 (Mean 56,31±14,27). On histopathological examination 30 cases of serous carcinoma, 21 mucinous cancer and 10 endometrial cancer were found.

Results: The expression of NRP2 with a strong degree of intensity was found in 7 cases, of low-grade 30 cases. No expression was found in 24 cases. There was no significant correlation between expression of neuropilin-2 and FIGO stage, tumor type or degree of histopathological differentiation.

Conclusion: Considering the results of the study, it is hard to define the role of neuropilin- 2 in lymphangiogenesis in oarian cancer.

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