Estrogens, insulin status and interrelated lifestyle factors on females with breast carcinomas

Abstract

Author(s): Alkhansa S. Mahmoud, Nagi I. Ali, Nouf H. Abuhadi, Baha Eldin Atta, Omer M. Abdalla, Ammar M. E. Hassan, Hussain M. Almohiy, Nayef Mohammed Alasmari, Khalid H. Bakheit

Background: lifestyle is a significant vital part of malignancy care, as well as metabolic health disorders, which could be a high-risk factor for breast cancer. The objective of this scientific work is to study at the time of diagnosis the changes in insulin, estrogens (Estradiol E2 and Estriol E3) concentrations and some other related lifestyle aspects as a risk factor of breast cancer. Materials and Methods: A total of 160 Sudanese women were subjected for study and then divided into two groups, 80 females were breast cancer patients against 80 other healthy women of matching the age and Body Mass Index (BMI) was acted as reference subjects. Smoking, medical prescriptions, physical activity BMI and nourishment behaviour were considered and studied as an individual lifestyle factor. Results: Upon comparison between premenopausal breast carcinoma subjects versus matching healthy volunteers, the insulin levels showed no significant difference as the (p-value was 0.08). While the estradiol (E2) concentration recorded a significant elevation with (p-value=0.001) and both E2 levels were within the reference values, the estriol (E3) values registered a significant drop of a p=<0.001. Concerning the postmenopausal patient’s comparison against the controls, although the insulin levels of both groups were exceeding the normal international range, correspondingly showed no significant variations between the same studded groups as p-value=0.2. Estradiol (E2) concentration of the patients showed a significant raise up comparing to the controlees with a p-value equivalent to 0.001, while estriol (E3) levels decreased in both postmenopausal groups cases patients and controls. Conclusion: In conclusion, high E2 levels found to be related to breast CAs of both premenopausal as well as postmenopausal females, while the low level of E3 was associated with only premenopausal breast CAs women. Poor metabolic healthiness could be a strong risk factor of having breast CAs irrespective to the Body Mass Index (BMI). Nutrition, maintaining a healthy weight, and physical activity may reduce the risk of breast cancer

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