Evaluation of humoral response in COVID-19 Saudi cancer patients

Abstract

Author(s): Nuha A. Alkhattabi, Nesrin I. Tarbiah

Background: SARS-Cov-2 caused a viral pandemic that started in late December 2019. This study aimed to investigate the humoral immunity response against SARS-Cov-2 by evaluating the B cell counts and serum levels of IgG and IgM in different groups of patients.

Methods: A total of 74 samples were collected from different groups of confirmed COVID-19 patients to evaluate the concentrations of IgG and IgM in groups including control, mild, severe, and asymptomatic. In addition, 84 samples were collected for CD19+ and CD27+ B cells analysis in the same group.

Results: Levels of IgG and IgM were found to be significantly elevated in COVID-19 patients; the severe groups showed the highest level among the groups of patients. Furthermore, a significant decrease in B cell counts in patients was observed.

Conclusion: Peripheral B cells, IgG and IgM were shown to be related to the severity of the disease. While CD19+ and CD27+ B cells tended to decrease in groups of patients, antibodies’ concentrations increased along with disease severity.

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