Evaluation of proteolytic enzymes in Iraqi patients with colorectal cancer

Abstract

Author(s): Noor Emad* and Firas A. Hassan

Background: Serine, aspartic and cysteine protease enzymes play a major role in Colorectal Cancer (CRC) progression. The objective of this article was to measure serine, aspartic, and cysteine protease enzymes in colorectal cancer patients and compare them with healthy subjects. Methods: Seventy newly diagnosed colorectal cancer patients were enrolled in the present study and divided as follows; Group A : (n=32) with an age range (of 20 years - 40 years); Group B : (n=38) with age range (41 years - 60 years). For comparison, a total of (30) healthy subjects were also inserted in the current study divided into patients in the same manner. Serum levels of serine, aspartic, and cysteine protease enzymes were measured for patients and controlled by the ELISA technique. Results: The current study shows that serum serine protease levels varied significantly in (the 20 years - 40 years) group when comparing the patient and control group (395.5 ng/ml vs. 71.61 ng/ml, p>0.0001) and also in (41 years - 60 years) group with mean 469.4 ng/ml vs. 106.3 ng/ml, p>0.0001, for patients and control groups respectively. Conclusion: Proteolytic enzymes including serum serine, aspartic, and cysteine protease were significantly increased in colorectal cancer patients when compared to healthy subjects.

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