Evaluation of the level of interleukin 18 in migraine patients in Diyala Governorate: Focus on Cancer

Abstract

Author(s): Mohammed Nasser, Ibtisam Badday Hassan

Migraine is a severe headache that comes in the form of attacks and is felt in one side of the head, and sometimes on both sides. It is accompanied by nausea, vomiting, and phobia of light and noise. Migraines have been classified into two main types: migraine without aura (MO) and migraine with aura (MA). There are many genetic, environmental and immunological factors that contribute to the occurrence of migraines, and migraines affect about (10-12%) of individuals at some time in their lives. This study was conducted in the period from October 15, 2022 to March 22, 2023, when 50 blood samples were collected from patients with migraine disease in private pathological analysis laboratories in several areas of Diyala Governorate. The study included the age group from (14-56) years, as it was The number of males is 13 and the number of females is 37. Also, 38 blood samples were collected from healthy people of both gender and used as a control group. The number of males was 25 and the number of females was 13 within the age group (18-56) years. The study included assessing the level of IL-18 concentration using ELISA Technique. The study found that the incidence of migraine in females was 74.0% higher than that of males, with an average age of (28.95±1.37) years, with a statistically significant difference between the gender with a value of (P>0.05). The results of the current study showed a slight increase in the level of IL-18 concentration in patients with migraine by (0.32±0.02 pg/ml) compared to the control group (0.31±0.01 pg/ml) and there is no statistically significant difference under the probability (P>0.05). Conclusion: This study concluded that the incidence of migraine is higher among females than males. IL-18: Interleukin is an important regulator of innate and immune responses and is involved in slowing the pain process, including neuropathic pain. Therefore, it is an anti-inflammatory cytokine, and a decrease in its concentration leads to an exacerbation of the severity of pain in migraine patients.

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