Examining the cancer women in a full course of betamethasone on mothers with leaks in weeks 34 to 36 of pregnancy

Abstract

Author(s): Zahra Naeiji, Zahra Fahmfam, Soraya Saleh Gargari, Atefeh Moridi, Nayereh Rahmati, Vedad khayatan, Arezoo Mehraban

Introduction: Corticosteroids cancers are prescribed to pregnant mothers for fetal lung maturation, but there is still much debate about their effects and side effects, complications arising from preterm birth and the high mortality rate in this group, and the conflicting results of similar studies, the need to investigate the effects of betamethasone administration in reducing postpartum complications in mothers with preterm labor at 34 weeks to 36 weeks of pregnancy. Therefore, this study aimed to find a 48 hour Expectant Management for these mothers to reduce these complications.

Materials and Methods: This cancer study is an interventional and clinical trial. The target population consists of mothers with preterm labor at 34 weeks to 36 weeks of pregnancy and newborns born at Mahdieh Hospital in Tehran, Iran. Individuals were randomly assigned to two groups, control and intervention. The intervention group received betamethasone along with ampicillin until the end of pregnancy, and the control group received only ampicillin until the end of pregnancy. After delivery, the prevalence of respiratory distress syndrome, tachypnea, need for oxygen or surfactant, jaundice, hypoglycemia, and neonatal mortality, as well as maternal outcomes including wound infection, amount of bleeding, antibiotic use, chorioamnionitis, and duration of hospitalization with betamethasone in two groups were recorded and compared.

Results: The mean age among mothers in the cancer control group was 29.39 years and among mothers in the intervention group was 25.97 years, with this difference being significantly higher in mothers in the control group. Out of 100 mothers in the control group, 45 had cesarean deliveries and 56 had vaginal deliveries, with no significant difference between the two groups. None of the mothers in either group experienced complications such as wound infection, chorioamnionitis, postpartum fever, or atony. In the control group, out of 100 newborns, there were 45 girls and 56 boys, while in the intervention group, there were 44 girls and 56 boys. The mean Apgar score at 1 minute and 5 minutes did not show a significant difference between the two groups, although both the 1 minute and 5 minute Apgar scores were higher in the intervention group. Invasive ventilation and NICU hospitalization were higher in the control group than the intervention group, and non-invasive ventilation and surfactant injection were higher in the intervention group than the control group, but this difference was not significant. Only one newborn in the intervention group died due to cancer, and among other indicators, no significant differences were observed between the two groups in terms of duration of hospitalization and jaundice.

Conclusion: Based on the results of the present study, a full course of betamethasone in mothers with preterm labor at 34 weeks to 36 weeks of pregnancy had no significant impact on pregnancy outcomes for the mother and fetus. None of the measured indicators in the study for infants showed a significant difference between the two intervention and control groups.

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