Exploring IgA Variation in Serum and Aqueous Humor of Ocular Toxoplasmosis Patients: Relevance for Radiotherapy (VMAT) Strategies

Abstract

Author(s): Haneen Ali Kareem, Shatha Khudiar Abbas

Toxoplasma.gondii is a protozoan eukaryotic parasite that can enter the body host as an obligate intracellular parasite and causes toxoplasmosis infection, it has the ability to cause latent infection in the host tissue such as cardiac muscle, skeletal muscles, or the central nervous system (Mendez et al.2017). Research into T. gondii in cancer patients is extensive. However, no one has yet discussed the implications of widespread parasite infection in this population. (Tarabulsi., 2020). Ocular toxoplasmosis (OT) is the infection of the eye caused by toxoplasmosis. Toxoplasma gondii infestation, which causes infectious posterior uveitis and consequent vision loss, is a significant health damage, particularly in developing nations (ADEGBEHINGBE, 2020). The study was carried out on 80 sample (50 are patients and 30 as a control) with age range (15-65) years, The serum level ( S.IgA) of the group was non-significantly increased in O.T. patients than controls, (107.84 ± 11.1 vs. 93.39 ± 9.67 pg/ml), (P= 0.329) . As well as, the serum level of S.IgA of the group was non-significantly increased in A.T. patients than controls, (100.06 ± 8.03 vs. 93.39 ± 9.67 pg/ml), (P= 0.607) . On the other hand, the serum level of S.IgA of the patients groups was nonsignificantly increased in O.T. patients than in A.T., (107.84 ± 11.1 vs. 100.06 ± 8.03 pg/ml), (P= 0.573). The level of Aqueous homer (A.IgA) of the group was significantly increased in O.T. patients than controls, (226.25 ± 12.14 vs. 191.78 ± 9.8 pg/ml), (P= 0.03) . As well as, the level of A.IgA of the group was nonsignificantly increased in A.T. patients than controls, (198.16 ± 12.4 vs. 191.78 ± 9.8 pg/ml), (P= 0.155) . On the other hand, the level of A.IgA of the patients groups was non-significantly increased in O.T. patients than in A.T., (226.25 ± 12.14 198.16 ± 12.4 pg/ml), (P= 0.112).

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