Correlation Between AP-1 and PDL-1 Gene Countenance in Patients with Hodgkin?s Lymphoma

Abstract

Author(s): Siham Jasim Al-kaabi, Azhaar Jasim Mohsin

EBV infection induces the countenance of PD-L1, which limits antitumor T cell responses by different and potential mechanisms, Here we highlight the estimation level of the AP1 transcription factor that acts as a double-edged sword with both oncogenic and tumor suppressive activities by control on the level of PD-L1 checkpoints in EBV-infected Hodgkin lymphoma patients. To our knowledge, This is the first Iraqi research attempt to explore the detailed mechanism of PDL1 upregulation by AP1 which is induced by EBV infection. The research including of 23 cases Hodgkin lymphoma and 10 healthy control, after diagnosis of EBV VCA IgG by using ELISA assay. Our result indicated that, the level EBV VCA IgG was positive in (10 ) cases Hodgkin lymphoma at a percentage (43.47%) while the absence of this antibody in control group at a rate (0.0%). Also, the mean of PDL-1gene significantly higher in Hodgkin lymphoma compared with mean of PD-L1 (2.2±1.84) in control , as well as , the statistical significant increased value of AP-1 in Hodgkin lymphoma (1.37 ±0.94) compared with control (1.07±0.38) , addition in this research we found significant correlation between AP-1and PDL-1 in EBV + Hodgkin lymphoma patients with (r= 0.40) at significant (p ≤ 0.05) .

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