Hollow Microneedles for Intradermal Hypericin Lipid Nanocapsule Delivery and Antitumor Effects

Abstract

Author(s): Mahendra Kumar Verma, Sumit Kumar Agrawal

Tumors provide a significant barrier to individual well-being and the overall health of the worldwide community. The unregulated proliferation and capacity for metastasis of these cells significantly contribute to global morbidity and death. The achievement of successful therapy necessitates using accurate medication delivery techniques, hence highlighting the need for developing novel methodologies. Conventional drug delivery methods often need help with variability in release rates, suboptimal cellular absorption, and inherent instability. The study introduces the Hollow Microneedles for Nanocapsule Delivery System (HM-NCDS) as a potentially practical and viable approach. The HM-NCDS technique utilizes microscopic needles to precisely administer drug-loaded lipid nanocapsules, thereby eliminating the limitations associated with current methodologies. The characteristics of the system include microneedles of about 201.5 µm, nanocapsules exhibiting an average drug loading capacity of 47.98%, regulated drug release rates with an average of 2.88 µg/hour, and effective cellular absorption with an average of 68.53%. The results indicate the potential for enhanced, focused, and uniform medication administration, presenting novel opportunities for tackling the worldwide impact of cancer, upgrading individual health results, and augmenting overall population welfare

Share this article