Inter-relationship between diabetes and breast cancer biomarkers

Abstract

Author(s): Jinseog Kim, Rabindra Nath Das, Youngjo Lee

The glucose metabolisms and serum lipid are assumed as possible intermediary mechanisms in linking between breast cancer (BC) and obesity. The current report examines the associations between diabetes mellitus (DM) markers (glucose and insulin) and BC markers (monocyte chemoattractant protein-1 (MCP-1), resistin, adiponectin, leptin). Glucose model shows that mean glucose levels are higher for breast cancer women (P=0.0222) then normal. Mean glucose levels are positively associated with leptin (P<0.0001) and homeostasis model assessment score insulin resistance (HOMA-IR) (P<0.0001), while they are negatively associated with interaction effects HOMA-IR*leptin (P<0.0001) and leptin*adiponectin (P=0.0883). On the other hand, variance of glucose levels is positively associated with HOMA-IR (P<0.0001) and resistin (P=0.0218), while it is negatively associated with leptin (P<0.0001), MCP-1 (P=0.0115). Insulin model shows that mean insulin levels are positively associated with HOM-IR (P<0.0001), leptin (P=0.0009), age*MCP-1 (P=0.0909), glucose*adiponectin (P=0.0424), glucose*resistin (P<0.0001), HOMA-IR*MCP-1 (P<0.0001), while they are negatively associated with MCP-1 (P=0.0264), resistin (P<0.0001), adiponectin(P=0.0783), glucose*HOMA-IR (P<0.0001), leptin*adiponectin (P=0.0713). Variance of insulin levels is higher for breast cancer women (P=0.0003) than normal. Again, it is positively associated with MCP-1 (P=0.0014), HOMA-IR (P<0.0001), while it is negatively associated with leptin (P=0.0828) and glucose*MCP-1 (P=0.0003). Many more relationships between BC and DM markers are also reported in the current article. It is concluded that both DM and BC markers have very complex closely interlinked relationships.

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