Management of acute promyelocytic leukaemia: A systematic study and meta-analysis

Abstract

Author(s): Yuvraj Parmar, Devanshu J. Patel, Mario Antony, Padmapriya G, Prabhat Sharma, Syam Bhargavan

A rare but severe variant of Acute Myeloid Leukemia (AML) known as Acute Promyelocytic Leukemia (APL) needs prompt medical attention. When APL is discovered during pregnancy, treatment options must be carefully assessed against any dangers to the growing fetus. This complicates APL management. To determine the effectiveness and safety of various treatment methods, a thorough study and meta-analysis of the therapy of APL during pregnancy was carried out. A comprehensive search of digital databases for papers released during 2000-2020 was part of the investigation. Once relevant articles had been located, they were further screened, and duplicates were removed. Moreover, 120 pregnant women confirmed to have APL were included in 78 studies that satisfied the criteria. Regardless of the induction method or gestational age, a complete remission frequency is 91%. Women in the first trimester had more excellent rates of spontaneous and induced abortion. The statistical analysis was performed using the SPSS software. There were just four stillbirths among third-trimester women. Respiratory distress syndrome affected 12 of the 16 new-borns with neonatal problems, but most of them (apart from 2 premature deaths) did well. According to this research's results, gestational age has little bearing on the mother's outcomes but is directly tied to fetal survivability. Our findings might help decide on a treatment that involves the individual being treated, a haematologist, a doctor who treats pregnant women, and a neonatologist.

Share this article