Metabolite identification of the gut microbes: Consequences for health and illness

Abstract

Author(s): Devanshu J. Patel, R. Jayanthi, Lokesh Verma, Nitin R. Nangare, Pravesh Kumar Sharma, Shikhar Gupta

Human gut microorganisms consume proteins and amino acids to make many chemicals, including branched-chain fatty acids, phenolic, indole, and sulfur compounds, many of which are harmful to the host. In the distal colon, where symptoms of diseases including Ulcerative Colitis (UC) and ColoRectal Cancer (CRC) frequently manifest, bacteria mostly ferment amino acids and proteins. The Gut Microbiota's (GM) proteolytic metabolism hasn't been studied as much as its glucose metabolism. With low molecular weight, volatile molecules make up a large portion of metabolites. This research's goal is to give a general indication of the use of analysis techniques to identify and evaluate substances to comprehend the connections among several dietary protein substrates, their related metabolites, and their effects on gastrointestinal health.

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