miRNA146-b expression as biomarker detection for papillary Thyroid Cancer

Abstract

Author(s): Hadel Kareem. AL-Rubaiawi*, Raid J. Mohamed and Sajid H. Alhelfy

Background: miRNA-146b is known as the post-transcriptional gene silencers, which is play important role in the regulating inflammatory responses. MicroRNAs (miRNAs) have been labeled as the promising molecular prognostic marker in several tumor types Thyroid cancer is the most common type of endocrine malignancy. Over the past few decades, the incidence of thyroid cancer has the considerably increased. Blood it is the most convenient and difficult to contaminate body fluid in diagnosis of diseases. The present study aimed to identify the most successful prognostic factors in well- defined thyroid carcinoma patients. One of the main objectives in this study is the miRNA 146b. Methods: By using Real time PCR, micro RNA-146b gene expression was measured in serum samples for 80 patients, 40 patients was diagnosed with papillary thyroid carcinoma and another 40 with benign thyroid goiter. Results: The current study revealed highly significant difference in median expression of miRNA-146b it was 47.3 folds (range=12.6- 281.11 folds) in TC patients compared to 10.23 folds (range=0.51- 134.83 folds) in those with BTT. Conclusions: Micro RNA-146b gene expression increased significantly in papillary thyroid carcinoma patients compared with benign thyroid goiter can be used for detection of thyroid cancer.

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