Mięsak gladkokomórkowy macicy – problemy diagnostyczne. Przegląd literatury

Abstract

Author(s): Dorota Teresińska, Wieslawa Bednarek, Agnieszka Puchalska-Kosiecz, Marcin Bobiński, Maria Mazurkiewicz

The aim of the study is to present the current state of knowledge on uterine leiomyosarcomas, with particular consideration of the role of proteins - p53, Ki-67, survivin, bax, and caspases - in these neoplasms. Leiomyosarcomas are rare neoplasms of the reproductive organs; still, they result in a considerably high mortality rate. Moreover, that type of neoplasms poses high diagnostic difficulties in clinical practice. Those features of leiomyosarcomas are stimuli for seeking new paths in their diagnosing as well as in therapy. In the recent years, an increasing importance has been attached to molecular studies focusing on an analysis of the role of proteins participating in cell proliferation (e.g. Ki-67) and controlling the mechanisms of apoptosis (caspases, p53, survivin, bax). The results of the studies are very promising and inspiring with hope for a quick development of clinical oncology.

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