NUT midline carcinoma of the lung

Abstract

Author(s): Khaoula Alaoui Ismaili*, Mohammed Ismaili, Imane Stitou, Yahya Morabiti, Meryem Zaryouhi, Lamiae Amaadour, Mariam Boubou, Hind Elfatmi, Karima Oualla, Zineb Benbrahim, Samia Arifi and Naoufal Mellas

NUT Midline Carcinoma (NMC) is a highly lethal, genetically defined, and rare undifferentiated cancer that occurs in the midline region of the mediastinum, head or neck.

We report in this study the case of a 35-year-old male who was diagnosed with a locally advanced mediastinal tumour. However, pathology with immunohistochemistry confirmed the diagnosis of poorly differentiated carcinoma and excluded the diagnosis of germ cell tumour (AFP BHCG markers negative). Although aggressively treated, the course was marked by a fast clinical deterioration which led to death within three months of the first diagnosis. The aim of this study is to highlight the rareness of this condition, the pathological and clinic-radiological characteristics, the management of the treatment and the prognosis.

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