Ocena tolerancji i skuteczności napromieniania całej wątroby u pacjentów z przerzutami raka jelita grubego

Abstract

Author(s): MARCIN BIAŁAS, JERZY WYDMAŃSKI, SŁAWOMIR BLAMEK, RAFAŁ SUWIŃSKI

Purpose: The aim of this study was to assess to effectiveness and tolerance of liver irradiation of hepatic metastases from colorectal cancer.

Material and method: Sixty patients (26 women and 34 men, 31-80 years old, median age 60) were treated between 03.1999 and 11.2005 with external beam irradiation. All of them were irradiated with 20 or 6 MV photons with two opposed fields technique to the total dose of 18 Gy in 10 fractions. Thirty eight (63%) of patients previously received chemotherapy according to 5-Fu + LV protocol. 18 (30%) of patients received chemotherapy of the second line. All patients were retrospectively assessed for response, toxicity, and survival.

Results: 59 (98%) of patients completed the treatment, only one patient didn’t complete the treatment because of deterioration of general performance status. The most frequent acute toxicity was mild to moderate nausea, it was observed in 9 (15%) patients. Before treatment 68% of patients suffered from hepatalgia, 5% of patients complained of nausea and 3% of patients of lumbalgia. 36 (60%) of patients demonstrated subjective response. Median duration of palliative effect was 3,8 months (range 1-18 months). Median survival was 8.7 months (range 1-34 months).

Conclusions: Whole liver irradiation due to colorectal metastases can be an effective and safe method of palliation, that might be considered in patients with progression after palliative chemotherapy.

Share this article