Patients' reports of chemotherapy adverse reactions in regular medical treatment: A Cohort Research of prevalence and severity

Abstract

Author(s): Geetika M. Patel, Rahul S. S, Deepthi Krishna, Megha Jagga, Rekha M. M, Sudhanshu Dev

Background: Despite frequently reporting these problems in clinical studies, there needs to be more data on the Frequency (F) of adverse effects of chemotherapy under regular clinical care. Aim: This study aimed to outline how frequently and severely patients at treatment facilities in India reported experiencing side effects from chemotherapy during routine visits.

Materials and Method: We performed prospective cohort research on people receiving lung, breast, or colorectal cancer chemotherapy. The side effects such patient’s encountered move reported through patients. For dividing a side effects' frequency, occurrence and incidence rates on kind and severity of each malignancy, cumulative incidence curves for each adverse outcome were generated. Secondary impact analysis using chi-squared statistics frequency was examined across demographic categories.

Result and Conclusion: Side effect information remains available for eligible patients with a 5.7 2-months median follow-up. During the trial period, 87% of individuals had at least one adverse effect and 28% of them, most frequently tired, experienced a grade IV side effect. Constipation (76%), diarrhea (75%) and fatigue (86%) were the most prevalent adverse effects overall 459. Different cancer types and side effects have comparable prevalence and incidence rates. Older adults are less likely to report age was only demographic and adverse impact characteristics linked to occurrence of side effects. The findings of this study are the first self-reported frequency of adverse effects from chemotherapy in standard clinical treatment to be estimated in India. Treatment side effects are frequent, persistent during treatment and even life-threatening in regular care. This study supports the idea that observational data are crucial for giving decision-makers information that is pertinent to clinical practice.

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