Prognostic study to detect ailments, including cancer, during solid organ transplantation to prevent postoperative complications using perioperative antibiotics therapy

Abstract

Author(s): Devanshu J. Patel, Prabhat Sharma, Asha K., Rashmi Gudur, Debrup Banerjee, Jagtej Singh

Objective: The purpose of this research was to examine the use of preoperative antibiotic therapy in solid organ transplantation to prevent postoperative complications. Methods: The data examined through PsycINFO and CINAHL conference papers, searches for resources that would be useful for our study. A conceptual study of randomized controlled trials and quasi-RCTs on antibiotic prophylaxis for solid organ transplant patients to avoid post-operative complication at any time after transplantation. Antibiotic resistance and surgical site infections were major findings. A model with unpredictable effects was employed to compute the RR and 95% CIs. Key findings were antibiotic resistance and surgical site infections. Using a random-effects model, we calculated RRs and 95% CIs. Results: 617 randomized participants. 237 randomized individuals compared antibiotics to no antibiotics, while 370 compared extended-duration to shortduration antibiotics. The evidence is extremely weak that antibiotics minimize surgical site infections. The other results were quite uncertain. There is some evidence that individuals who have had solid organ transplants may benefit from using extended-duration antibiotics to avoid surgical site infections. None of the 7 studies examined possible harmful effects on grafts, heart disease, malignancy, life expectancy, haematological and biological indicators, length of hospital stay, cost of assistance, or hospitalisation charges. Conclusion: Available information on the effectiveness of pre-operative antibiotic prophylaxis for organ transplantation is of very low-quality owing to methodological constraints, bias risk, and high heterogeneity. More excellent RCTs with sufficient power would improve clinical practice.

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