Prognostic value of CK14 expression in urinary bladder cancer

Abstract

Author(s): Rasha Ali Akar, Hameed Naeem Mousa, Satar Abood Faris

The aim of current study is to determine the expression of the CK14 protein in human bladder cancer, and demonstration of correlations between this parameter and clinical pathologic variables as (grade and stage of tumor), and also by using this marker can classify bladder cancer in to basal and luminal type. The current study is designed to detect the role of Ck14 expression in bladder carcinoma as a possible marker for detecting the biological behavior of malignancy and its correlation with grade and muscle invasiveness for both diagnostic and prognostic purposes. The study focuses on a technique of immunohistochemistry for detection Ck14 expression in bladder cancer. The samples are collected randomly in southern Iraq, in AL-Nasiriya city, from AL Hussein teaching hospital. Number of samples is (100) samples, (70) bladder cancer tissue and (30) controls benign tissue. Results of this study reveal that Ck14 expression is positive in 45 out of 70 sample. The study present showed Ck14 expression is increased in high grade bladder cancer represent (86.0%), while in low grade (29.6%), CK14expression high in advanced tumour stages T3, T4 percentage (100%) and T2 stage (87.2%), expression of CK14 low in early tumor stages Ta (26.3) T1(33.3). expression CK14 excessive in muscle invasive (97.6%), whereas the expression CK14 is low in non-muscle invasive type (28.6%). So Ck14 can be used as a marker for assessment of bladder cancer aggressiveness. This study represents an important step because there is absence of studies about this topic in Iraq.

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