Prostate cancer and cardiovascular disease: Correlated?

Abstract

Author(s): Shipra Banik, Mahashweta Das, Ishita Saha, Rui Gong, Poonam Singh, Jinseog Kim and Rabindra Nath Das*

Many authors have reported that Prostate Cancer (PC) and Cardiovascular Disease (CVD) are strongly associated, while it is not yet well established. The current report examines this fundamental query by examining the associations of a PC biomarker known as serum Prostatic Acid Phosphatase (PAP) with CVD risk factors such as Diastolic Blood Pressure (DBP), Systolic Blood Pressure (SBP), along with CVD history, and classified CVD patients based on Electrocardiogram (EKG) status, and conversely. It is derived herein that PAP has no association with SBP and DBP, while the mean PAP level is significantly higher for non-CVD subjects (P=0.0179), than for CVD patients. The variance of PAP level is significantly more scattered for CVD patients (P=0.0190) than normal, and also it is significantly more scattered for normal subjects based on EKG (P=0.0249), than the others. On the other hand, the mean and variance of DBP have no relation with PAP. Only the variance of DBP is significantly more scattered for normal subjects (P=0.0004) than PC patients, and it is significantly more scattered for PC patients with bone metastases (BM) (P=0.0021) than normal. Again, mean SBP decreases (P=0.0621) if PAP rises, while it increases as the primary tumor size (P=0.0054) increases. A similar association is observed for the variance of SBP with PAP, that is SBP variance is negatively associated with PAP (P=0.0045). It can be concluded that the association between PC and CVD exists, which should be considered for the medical treatment process.

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