Retrospective analysis of eight cutaneous Kaposi?s Sarcoma cases treated by radiation therapy

Abstract

Author(s): Farhane Fatima Zahra*, Zenab Alami, Wissal Hassani and Touria Bouhafa

Background: Kaposi’s Sarcoma (KS) is an angioproliferative disease, with a viral aetiology and a multifactorial pathogenesis that depends on an immune dysfunction. It is frequently presents with multiple skin lesions and may also involve lymph node, mucosa, and visceral involvement.

Objective: The aim of this study was, especially, to describe the place of the radiation therapy in the management of cutaneous Kaposi’s sarcoma through the experience of the department of radiotherapy of HASSAN II university hospital about 8 KS patients.

Methods: Medical records of 8 cutaneous KS patients treated by radiotherapy between June 2012 and December 2019 were evaluated retrospectively.

Results: There were as many females as male (male-to-female ratio was 1/1). The median age at diagnosis was 80 years (range, 35 years-89 years). All KS patients in this study except one were classic KS. The lower extremities were the most commonly involved area. Radiotherapy was used in all our patients. Complete response rate was 38% (defined as a clinical complete regression of tumour lesion) was 38%, partial response rate (defined as a reduction in tumour lesion size more than 50) was 62,5%. The control of symptoms (especially pain, bleeding and pruritus) was always achieved. Side effects were limited.

Conclusion: RT is an effective and safe treatment for local treatment of KS. We report our experience in the management of this disease.

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