Skuteczność paliatywnej teleradioterapii w stosunku do objawów związanych z miejscowym rozrostem niedrobnokomórkowego raka pluca. Analiza 1350 chorych

Abstract

Author(s): Tomasz Walasek, Marian Reinfuss, Jerzy Jakubowicz, Piotr Skotnicki, Pawel Blecharz, Marcin Hetnal, Elżbieta Pluta, Andrzej Kukielka, Piotr Brandys

Purpose: To assess palliative effect of chest teleradiotherapy in reducing symptoms of locoregional tumor growth in patients with advanced non-small cell lung cancer.

Materials and methods: Analysis was conducted in the group of 1350 patients with disturbing, moderate to severe symptoms: cough in 45,2% of patients, hemoptysis – 20%, chest pain - 18,5%, dyspnoea – 14,4%, hoarseness - 8,1% and swallowing difficulties – 6,0%. Patients were included in the symptomatic response assessment. Good palliative effect of the treatment were disappearance (CR) or improvement (PR) of a most disturbing symptom of at least 1 point in 4 point scale (0 – without symptoms, 1 – mild, 2 – moderate, 3 – severe symptoms).

Results: The best palliative effect was obtained in patients suffering from hemoptysis (CR=70%, CR+PR=84%), chest pain (CR=60,8%, CR+PR=72%) and in patients with cough (CR=34,9%, CR+PR=64,9%). Relatively good palliative effect was obtained in patients with dyspnoea (CR + PR=42,1%) and hoarseness (CR+PR=35,5%), weak palliative effect in patients with swallowing difficulties (CR+PR=14,8%).

Conclusions: Palliative teleradiotherapy was effective in reducing hemoptysis, cough and chest pain, less effective in reducing dyspnoea and hoarseness and not enought effective in patinets with swallowing disturbances.

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