Smart size-tunable drug delivery nanosystems and tumor microenvironment priming for deepened penetration

Abstract

Author(s): Shikha Kumari Rajak, Vinay Jaiswal, Krishna Sahu

Cancer continues to pose a significant global health obstacle, requiring the development of novel approaches in medicine administration to address its intricate nature. The Tumor Micro-Environment (TME) poses a substantial barrier to the successful delivery of drugs, often impeding drug diffusion and restricting therapeutic efficacy. Developing sizetunable drug delivery nanosystems has emerged as a viable approach, potentially boosting drug delivery efficiency. This study article explores the advancement of Smart Size-Tunable Drug Delivery Nanosystems (S2TD2-NS) and the manipulation of the tumor microenvironment to enhance drug penetration at greater depths. The drug delivery platform S2TD2-NS utilizes the distinctive characteristics of (R)-(+)-α-Lipoic Acid to enhance drug encapsulation, resulting in a highly effective drug delivery system. The study's findings demonstrate a mean encapsulation effectiveness of 89.33%, a fluorescence intensity ratio 1.33, a decrease in tumor volume to 722.88 mm³, and a minimal heat production at 37.6°C. The S2TD2-NS technology provides a promising way to mitigate existing constraints in drug delivery, hence opening new opportunities for developing enhanced cancer therapy techniques

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