Study anticancer activity of the prepared compound compound3-({2-[5-(2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]hydrazinylidene}methyl)benzene-1,2-diol..

Abstract

Author(s): Hadeel H. Jasim, Ibrahim A. Flifel

The current study paid attention to the preparation of a chemical compound 3-({2-[5-(2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]hydrazinylidene}methyl) benzene-1,2-diol and its complexes. This ligand was used as an anti-cancer agent, as it gave high efficacy when tested on normal cells and cancer cells. This compound was also used as an antioxidant when compared with vitamin C. It was found to have high efficacy at low concentrations. This study included three axes, the first axis synthesis of chemical compound compound3-({2-[5- (2-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]hydrazinylidene}methyl)benzene-1,2- diol and its complexes with Ni(??), Co(II),Cr(???) ions. In addition, characterization by mass spectra, H1-NMR and FTIR. The hyper-chem study of transition metal complexes suggests octahedral geometry for Cr⁺³ ion, square planer geometry for Ni⁺², and Co⁺², suggesting tetrahedral geometry. In the second step, the ligand was tested as an anticancer activity also, In the third step the prepared ligand showed good anticancer.

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