Survival patterns and clinicopathologic spectrum of Glioblastoma Multiforme (GBM)- experience at a tertiary cancer centre in South India

Abstract

Author(s): Sithara Aravind, Noushad Aryadan*, Arun Narendran and Sangeetha K Nayanar

Objective: Glioblastoma Multiforme (GBM) is the most common CNS malignancy worldwide. There is few data regarding this entity in South Indian population. Our objective is to evaluate the demographic, clinicopathologic, treatment and survival characteristics of this entity. Materials and Method: A retrospective single centre study of 5 years (2013-2017) duration. Data of patients with tissue diagnosis of GBM, treated at Malabar Cancer Centre was studied. Results: A total of 30 cases of GBM are studied. Male predominance noted with mean age of presentation 54.5 years. 93% cases are primary GBM. The tumours are predominantly left sided (57%) with frontal lobe being the most commonly affected site. The most common histological type is GBM-NOS .Surgery is the primary treatment modality undergone by 97% of cases followed by adjuvant concurrent chemo radiation (83%). In a median follow up period of 26 months, 5 are alive without disease, 7 are alive with disease, 14 succumbed to disease, and 4 lost to follow up. The median Overall Survival (OS) is 17 months and the median Disease Free Survival is 12 months. All patients who survived beyond the median OS, where termed as Long Survivors (LS) and their characteristics were analysed. Conclusion: Multi-centric studies on demographic and survival features of GBM are of great importance in establishing Indian geographic epidemiology. Specific features of GBM with better survival warranties further studies aimed at molecular characterisation and targeted treatment protocols.

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