Synthesis of surfactant?modified ZIF?8 and its application in drug delivery and tumor therapy

Abstract

Author(s): Lukeshwari Sahu, Moniza Nurez Khan, Neetish Kumar

Metal-Organic Frameworks (MOFs) represent a distinct category of crystalline substances consisting of metal ions or clusters interconnected by organic linker molecules. These materials exhibit remarkable porosity, surface area, and adjustable properties, rendering them highly versatile. Metal-organic frameworks (MOFs) are known for their diverse applications, encompassing gas storage, catalysis, drug delivery, and separation processes. This versatility stems from their inherent capability to selectively adsorb and desorb gases, liquids, and various other substances in a regulated fashion. Nevertheless, regulating the microstructure of Metal-Organic Frameworks (MOFs) remains a significant challenge in enhancing drug delivery efficiency and achieving sustained release behavior, thereby posing a hurdle for their clinical application. This paper presents a methodology for synthesizing Surfactant-Modified Zeolitic Imidazolate Framework-8 nanoparticles (SSM-ZIF-8) with varying microstructures. The method involves the utilization of different surfactants to alter the ZIF-8 material. The nanoparticles of ZIF-8 that have been modified with surfactants exhibit a greater Specific Surface Area (SSA) and larger Total Micropore Volumes (TMV) than the unmodified ZIF-8. This enhanced characteristic allows for a more efficient Doxorubicin (DOX) loading onto the drug carriers, leading to a regulated and long-lasting absorption of the drug. The exceptional degradation performance exhibited by ZIF-8 Nanoparticles (NP) enhances the metabolic processes of drug carriers. The porous architecture of the modified ZIF-8, in conjunction with surfactant improvements, facilitates effective drug encapsulation and regulated drug release in the field of drug delivery. This has the potential to enhance therapeutic efficacy while mitigating adverse effects. In the tumor therapy framework, utilizing this modified material holds the potential for targeted delivery of anticancer drugs to tumor sites, thereby optimizing the effectiveness of treatment and reducing systemic exposure. Consequently, this approach can potentially enhance the prospects for cancer therapy. The research comprises both the synthesis of the element and its possible utilization in the medical domain.

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