The association of peri-tumoral vascularity and stage, grade, and histopathologic features in renal cell carcinoma

Abstract

Author(s): Morteza Mohammad Mirzaei, Ayda Roostaee, Ghazaleh Dezyani* and Behzad Askari

Aims and Objectives: This study aimed to investigate the relationship between the presence of peritumoral vessels in CT scan images of Renal Cell Carcinoma (RCC) patients, the histopathological status of the tumor, and the TNM stage of the tumor.
Methods and Materials: This retrospective study was conducted by reviewing the clinical records of patients. The histopathological information of the patients, encompassing the grade and the histological type of the tumor was extracted. The images of the CT scan and other imaging modalities were then reviewed by an experienced radiologist to determine the TNM stage of the tumor and presence of peritumoral vessels. Logistic regression analysis was performed to assess the predictive power of the presence of peritumoral vessels in determining the pathology and stage of the tumor.

Results: We included 66 patients in our study. The mean age was 69 ± 6.4 among the patients. Among 20 patients with detected peri-tumoral vein, 18 (90%) had T3 stage cancer (p-value=0.041), 11 (55%) had N1 stage cancer (p-value=0.009), and 6 (30%) had present metastasis (p-value=0.011). Existence of peri-tumoral vein was significantly associated for 5.66 times increased odds of higher stage T cancer, 4.55 times increased odds lymph node involvement, and 6.14 times increased odds of having metastasis. Further detail regarding 95% CI and significance level is summarized in Table 2.

Conclusion: The existence of collateral vessels exhibited a significant correlation with aggressive clinicopathological features, poor differentiation, and poor staging. This relationship emphasizes its relevance to the selection of RN and open surgery in clinical decision-making.

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