The development of carcinoma chemotherapy prevention agents using animal models

Abstract

Author(s): Tejaswi* and Amit Nayak

Animal models are commonly used to evaluate the effectiveness of potential chemo preventive agents, including synthetic chemicals, natural products, and combinations thereof. These models help identify which agents are safe and effective for use in clinical chemoprevention trials. Organ-specific animal models are used to determine which agents are most effective for preventing specific forms of cancer without causing toxicity. These models can be induced with cancer-causing agents or created using transgenic or mutant animals. Various animal tumour models are available for chemoprevention research and are used to test combinations of agents, evaluate routes of administration, and generate pharmacokinetics and toxicology data. There is a strong correlation between outcomes of animal and human chemoprevention trials, with positive results in animal testing generally leading to positive results in humans. However, further human data is needed to validate the efficacy of animal models in predicting the success of agents in human trials. Regardless, animal efficacy data remains essential for clinical trial decision making.

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