The Effect of Anti-Adhesive Agent on Patients with Low Anterior Resection Syndrome

Abstract

Author(s): Nahm-Gun Oh, Hyun Sung Kim, Hyeon Yu

Objective: This study aimed to evaluate the efficacy of the anti-adhesive agent in enhancing bowel function after a low anterior resection in patients diagnosed with rectal cancer.

Methods: From January 2006 to December 2020, we analyzed the prospective data of 112 patients with laparoscopic low anterior resection. The patients were divided into Anti-adhesive (n=54) and non-adhesive (n=58). The assessment of bowel function was conducted between 3 months to 24 months following surgery. It was evaluated by personal interviews (incontinence status), and by anorectal manometry.

Results: Of 112 patients, the mean age was 63.0 years. The mean frequency (p=0.041), urgency (p=0.036), and seepage (p=0.039) of bowel movements were significantly higher statistically in the study group in 3 months postoperatively. In 2 years, fecal incontinence score was significantly improved in in study group (p=0.025). In 24 months of follow-up, the study group showed a considerable increase in Maximum Anal Squeezing Pressure (MASP) from 146.3 mmHg to 178.9 mmHg (p=0.002), but no statistical differences were found between 2 groups during the follow-up period (p=0.838).

Conclusion: Applying an anti-adhesive agent to the pelvic cavity after laparoscopic low anterior resection in rectal cancer patients may reduce postoperative bowel movement dysfunction.

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