The molecular subtypes configuration of metastatic breast cancer in Basrah city

Abstract

Author(s): Rafid Adil Abood Alkhalidy*

Globally, Breast Cancer (BC) is the second and the first of the top ten cancers in the world and Iraq, respectively. The configuration of molecular subtypes on metastatic BC (MBC) for rebuilding the implications on the management. This study aimed to describe the clinicopathologic properties and metastatic configuration of molecular BC subtypes. This is a retrospective study of 500 MBC females from Basrah city, Iraq. The study was conducted at Basrah Oncology Center, for a period from June 2010 to June 2021. The HR expression status and HER2 gene amplification were evaluated by IHC. The associations of molecular subtypes and distant metastases are modelled by regression analysis. The most common age group belonged to 41years-50 years in (144, 28.8%). A total of 59 of 500 women have a positive family history of cancer. The most common histology in this study is IDC (430, 86%). The intermediate grade was recorded in most patients (311, 62.2%). Bone was the most common site of secondaries in (174, 34.8%) of patients. The ER was positive in 294(58.8%), and PR positive in 328(65.6%). The HER 2neu negative more than positive [298(59.6%) vs. 202(40.4%)]. The HR+/Her2neu– (Luminal A) was the prevalent molecular subtypes. None of the variables was significantly associated with metastasis to bone, pulmonary, liver, brain, chest wall, LN, or pleura, except the age of patients, BMI, HR+ and HER 2 neu (P=0.02), (P=0.05), (P=0.01), and (P=0.01), respectively, showed strong affection with the metastatic pattern. The commonest age of BC in our locality is more than fifty years. High BMI has high infinity on the development of BC. The bone is the most common site of secondaries. All metastasis sites are strongly associated with molecular phenotypes patterns. Molecular phenotypes show different behaviour of metastasis concerning the sites.

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