The Physical Parameters Variation Related to the Standard Uptake Value and Mass Activity in the Benign and Malignant Adrenal gland

Abstract

Author(s): Maryam Amer M* and Nadiya Y Mohammed

Background: This study is to evaluate the benign and malignant of adrenal mass using physics parameters of standard uptake value and mass activity through pet/CT scan.

Materials and Methods: The study involved 47 patients which were diagnosed with adrenal gland tumors by a nuclear medicine physician. Before the PET/CT scan, patients must adhere to specific fasting protocols, including abstaining from carbohydrates and sugars for 12 hours and from food for 6 hours. However, they were being permitted to consume water. Patient is injected intravenously by 18-FDG with 0.1 mci per kilogram of body weight. The volume of interest (VOI) and Region of interest (ROI) was determined manually or semi-automatically. The physics parameters used in this study are Adrenal Mass Activity 3D and 2D (MBq), Adrenal Max SUVs (MBq/ml)

Results: According to the Pet /CT scan image, blood test and adrenal biopsy, the patients were divided into two groups based on tumor type: 38 patients had malignant, and nine were benign. Patients in benign and malignant groups showed no significant differences in age, gender, height, weight, BMI, glucose level, fasting duration, and FDG-18 dose. The Adrenal Mass Activity 3D (MBq) for the malignant group was significantly higher than the benign group, and the maximum adrenal standard uptake values (SUV) were significantly higher. A correlation test was conducted between the injected Dose (ID in MBq) of FDG-18 and the three parameters: 3 Dimensions, Adrenal mass activity in 2 Dimensions (MBq), and the maximum standard uptake values (SUV) (MBq/ ml). The analysis showed no significant correlation between the ID and the 3 Dimensions, 2 Dimensions, or SUV for both malignant and benign.

Conclusions: The variation in standard uptake value and activity of FDG-18 can be added as a physical parameter to differentiate between benign and malignant in adrenal mass diagnostic.

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