The Role of pD_L1 expression in bladder cancer

Abstract

Author(s): Awatif Z. Abdiwi, Prof. Dr. Husam Mohammad, Asst. Professor. Hameed Naeem Mousa

The aim of this study is to determine the expression of the PD_L1protein in human bladder cancer, and significant correlations between these parameters and clinico pathologic variables like (grade and stage), and also by using this marker can classify bladder cancer in to basal and luminal type. the bladder cancer is one of the most common cancers worldwide. the incidence and mortality of this disease increased during last decades alarmingly in Iraq. The current study is designed to detect the role of pD_L1 expression in bladder carcinoma as a possible marker for detecting the biological behavior of malignancy and its correlation with grade and muscle invasiveness for both diagnostic and prognostic purposes. The study focuses on a technique of immunohistochemistry for detection pD_L1 expression in bladder cancer. The samples are collected randomly in southern Iraq, in AL-Nasiriya city, from AL Hussein teaching hospital. Number of samples is 100 ,70 bladder cancer tissue and 30 controls benign tissue. Results of this study reveal that pD_L1 expression is positive in 45 of 70 sample. The study demonstrated pD_L1 expression is increased in high grade bladder cancer represent (44.19%), while in low grade (33.33%), pD_L1 expression high in T2 stage (41.03%) , and in Ta( 26.3%) T1( 33.3%) T3 (50%) T4( 100%). expression pD_L1 excessive in muscle invasive (42.86%), whilst the low expression for pD_L1 in the non-muscle invasive type (35.71) So pD_L1 can be used as a marker for assessment of bladder cancer aggressiveness. This study represents an important step because there are few of studies about this topic in Iraq; we are needing more studies to prove the function of this pD_L1 in biological behavior of bladder cancer

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