The role of prostate size in determining serumic PSA values in patients with benign prostatic hypertrophy

Abstract

Author(s): Neziri A., Demaci Sh., Cuni Xh., Miftari I., Selmani L.

Objective: To determine relationship between prostate volume and serum values of Prostatic Specific Antigen (PSA) among men with Lower Urinary Tract Symptoms (LUTS) caused by Benign Prostatic Hyperplasia (BPH).

Material and Methods: Prospective and retrospective 1420 patients classified in four age-groups with LUTS were analyzed. Patients were treated for BPH in the urology clinical at the University Clinical Center of Kosovo during the period of January 2010-October 2020. Data were recorded from patients according to age, prostate size estimated by transabdominal ultrasound using 3.5MHz ultrasonography, according to the ellipsoid formula, V=D1xD2xD3/2.5, volume of prostate, V=TxAPxCCxPi/6 where T=Transverse diameter, AP=Antero Posterior diameter, CC=Cranial Caudal diameter. Patients with confirmed prostate cancer were excluded from the study. Statistical analyses used t-test and ANOVA with 95 and 99% confidence intervals.

Results: Mean prostate volume and concentration of serum PSA for the total 142 patients in the study were 46.8 cm³ and 3.5 ng/mL, respectively. It is clear that the both values rises with aging. The mean prostate volume and concentration of serum PSA in the different age- groups respectively were 33.2 cm³ and 1.8 ng/mL (50 years-59 years-old), 37 cm³ and 3.1 ng/mL (60- 69 years-old), 49.2 cm³ and 5.1 ng/mL (70 years-79 years-old), and 49.2 cm³ and 5.1 ng/mL (80 years-89 years-old).

Conclusions: The data confirms that prostate volume and PSA concentration of serumic PSA have significant correlation and rises with aging.

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